The Revenge of Cracklin

Plot
Ms Cracklin comes back from the dead after Gloxie killed her and kills the Idiot Squad. Megamind, after fucking Antonio, comes back to fight her. Before she is defeated, Cracklin flies away, and is never seen again.

Trivia

 * this is the season 1 finale
 * this is the first episode to not focus on the Idiot Squad
 * there is a lot of Antonio and Megamind background moments